Publications

Google Scholar Profile

 ORCID iD

  1. Helena Gien, Michael Morse, Micah J. McCauley, Ioulia Rouzina, Robert J. Gorelick, and Mark C. Williams. Cationic Residues of the HIV-1 Nucleocapsid Protein Enable DNA Condensation to Maintain Viral Core Particle Stability During Reverse Transcription. Viruses 16: 872 (2024).
  2. Ryan C. Burdick, Michael Morse, Ioulia Rouzina, Mark C. Williams, Wei-Shau Hu, and Vinay K. Pathak. HIV-1 uncoating requires long double-stranded reverse transcription products. Science Advances 10: eadn7033 (2024).
  3. Ben A. Cashen, Michael Morse, Ioulia Rouzina, Richard L. Karpel, and Mark C. Williams. C-terminal domain of T4 gene 32 protein enables rapid filament reorganization and dissociation. Journal of Molecular Biology 436: 168544 (2024).
  4. Joha Joshi, Micah J McCauley, Michael Morse, Michael R. Muccio, Joseph G. Kanlong, Márcio S. Rocha, Ioulia Rouzina, Karin Musier-Forsyth, and Mark C Williams. Mechanism of DNA Intercalation by Chloroquine Gives Insights into Toxicity. International Journal of Molecular Sciences 25: 1410 (2024).
  5. Micah J. McCauley, Joha Joshi, Nicole Becker, Qi Hu, Maria Victoria Botuyan, Ioulia Rouzina, Georges Mer, L. James Maher III, and Mark C. Williams. Quantifying ATP-Independent Nucleosome Chaperone Activity with Single-Molecule Methods. In: Heller, I., Dulin, D., Peterman, E.J. (eds) Single Molecule Analysis. Methods in Molecular Biology, vol 2694. Humana, New York, NY (2024).
  6. Michael Morse*, Francesco Navarro Roby*, Mansi Kinare, James McIsaac, Mark C. Williams, and Penny J. Beuning. DNA damage alters binding conformations of E. coli single-stranded DNA binding protein. Biophysical Journal 122: 3950-3958 (2023). *contributed equally
  7. Ben A. Cashen, Michael Morse, Ioulia Rouzina, Richard L. Karpel, and Mark C. Williams. Dynamic structure of T4 gene 32 protein filaments facilitates rapid noncooperative protein dissociation. Nucleic Acids Research 51: 8587–8605 (2023).
  8. Michael Morse, Jana Sefcikova, Ioulia Rouzina, Penny J. Beuning, and Mark C. Williams. Structural domains of SARS-CoV-2 nucleocapsid protein coordinate to compact long nucleic acid substrates. Nucleic Acids Research 51: 290-303 (2023)
  9. Micah J. McCauley, Michael Morse, Nicole Becker, Qi Hu, Maria Victoria Botuyan, Emily Navarrete, Ran Huo, Uma M. Muthurajan, Ioulia Rouzina, Karolin Luger, Georges Mer, L. James Maher III, Mark C. Williams. Human FACT subunits coordinate to catalyze both disassembly and reassembly of nucleosomes. Cell Reports 41: 111858 (2022).
  10. Mark C. Williams and Michael Morse. Review of “S373P Mutation of Spike Protein in SARS-CoV-2 Stabilizes Omicron.” Rapid Reviews: COVID-19 (2022)
  11. Ben A. Cashen, M. Nabuan Naufer, Michael Morse, Charles E. Jones, Mark C. Williams, and Anthony V. Furano. The L1-ORF1p coiled coil enables formation of a tightly compacted nucleic acid-bound complex that is associated with retrotransposition Nucleic Acids Research 50: 8690-8699 (2022).
  12. Adam A. Jabak, Nicholas Bryden, Fredrik Westerlund, Per Lincoln, Micah J. McCauley, Ioulia Rouzina, Mark C. Williams, and Thayaparan Paramanathan. Left vs. Right: Exploring the Effects of Chiral Threading Intercalators using Optical Tweezers Biophysical Journal 121: 3745-3752 (2022).
  13. Helena Gien, Michael Morse, Micah J. McCauley, Jonathan P. Kitzrow, Karin Musier-Forsyth, Robert J. Gorelick, Ioulia Rouzina, Mark C. Williams. HIV-1 nucleocapsid protein binds double-stranded DNA in multiple modes to regulate compaction and capsid uncoating. Viruses 14: 235 (2022).
  14. M. Nabuan Naufer, Michael Morse, Guðfríður Björg Möller, James McIsaac, Ioulia Rouzina, Penny J. Beuning, and Mark C. Williams. Multiprotein E. coli SSB-ssDNA complex shows both stable binding and rapid dissociation due to interprotein interactions Nucleic Acids Research 49: 1532-1549 (2021).
  15. Mark C Williams and Akira Ono. Introduction to Special Issue “The 11th International Retroviral Nucleocapsid and Assembly Symposium” Viruses 12: 1243 (2020).
  16. Micah McCauley, Ioulia Rouzina, Jasmine Li, Megan Nunez, Mark C Williams. Significant differences in RNA structure destabilization by HIV-1 GagΔp6 and NCp7 proteins. Viruses 12: 484 (2020).
  17. M. Nabuan Naufer and Mark C. Williams. Characterizing Complex Nucleic Acid Interactions of LINE1 ORF1p by Single Molecule Force Spectroscopy. Methods in Molecular Biology 2106: 283-297 (2020).
  18. Micah J. McCauley, Ioulia Rouzina, and Mark C. Williams. Specific Nucleic Acid Chaperone Activity of HIV-1 Nucleocapsid Protein Deduced from Hairpin Unfolding. Methods in Molecular Biology 2106: 59-88 (2020).
  19. Michael Morse, M. Nabuan Naufer, Yuqing Feng, Linda Chelico, Ioulia Rouzina, and Mark C. Williams. HIV restriction factor APOBEC3G binds in multiple steps and conformations to search and deaminate single-stranded DNA. eLife 8: e52649 (2019).
  20. Ali A. Almaqwashi, Wen Zhou, M. Nabuan Naufer, Imogen A. Riddell, Ömer H. Yilmaz, Stephen J. Lippard, and Mark C. Williams. DNA intercalation facilitates efficient DNA-targeted covalent binding of phenanthriplatin. Journal of the American Chemical Society 141: 1537-1545 (2019).
  21. M. Nabuan Naufer, Anthony V. Furano, and Mark C. Williams. Protein-Nucleic Acid Interactions of LINE-1 ORF1p. Seminars in Cell and Developmental Biology 86: 140-149 (2019).
  22. Micah J. McCauley, Ran Huo, Nicole Becker, Molly Nelson Holte, Uma M. Muthurajan, Ioulia Rouzina, Karolin Luger, L. James Maher III, Nathan E. Israeloff, Mark C. Williams. Single and double box HMGB proteins differentially destabilize nucleosomes. Nucleic Acids Research 47: 666-678 (2019).
  23. Yuqing Feng, Lai Wong, Michael Morse, Ioulia Rouzina, Mark C. Williams, and Linda Chelico. RNA-mediated dimerization of the human deoxycytidine deaminase APOBEC3H influences enzyme activity and interaction with nucleic acids. Journal of Molecular Biology 430: 4891-4907 (2018).
  24. Micah McCauley, Ioulia Rouzina, and Mark C. Williams. Constructing Free Energy Landscapes of Nucleic Acid Hairpin Unfolding. In DNA Nanotechnology, Giampaolo Zuccheri (Ed), Methods in Molecular Biology 1811: 315-332 (2018).
  25. Kiran Pant, Brian Anderson, Hendrik Perdana, Matthew A. Malinowski, Aye T. Win, Christopher Pabst, Mark C. Williams, and Richard L. Karpel. The Role of the C-Domain of Bacteriophage T4 Gene 32 Protein in ssDNA Binding and dsDNA Helix-Destabilization: Kinetic, Single-Molecule, and Cross-Linking Studies PLoS ONE 31: e0194357 (2018).
  26. Micah J. McCauley, Leah Furman, Catherine A. Dietrich, Ioulia Rouzina, Megan E. Núñez, and Mark C. Williams. Quantifying the stability of oxidatively damaged DNA by single-molecule DNA stretching. Nucleic Acids Research 46: 4033-4043 (2018).
  27. Micah J. McCauley and Mark C. Williams. The elusive keys to nucleic acid stability: Comment on “DNA melting and energetics of the double helix” by Alexander Vologodskii and Maxim D. Frank-Kamenetskii. Physics of Life Reviews 25: 37-39 (2018).
  28. Andrew G. Clark, M. Nabuan Naufer, Fredrik Westerlund, Per Lincoln, Ioulia Rouzina, Thayaparan Paramanathan, Mark C. Williams. Reshaping the energy landscape transforms the mechanism and binding kinetics of DNA threading intercalation. Biochemistry 57: 614-619 (2018).
  29. Michael Morse, Ran Huo, Yuqing Feng, Ioulia Rouzina, Linda Chelico, and Mark C. Williams. Dimerization regulates both deaminase-dependent and deaminase-independent HIV-1 restriction by APOBEC3G. Nature Communications 8: 597 (2017).
  30. Akira Uchida*, Divakaran Murugesapillai*, Markus Kastner, Guinevere V. Oliver, Yao Wang, Maria F. Lodeiro, Shaan Prabhakar, Jamie J. Arnold, L. James Maher III, Mark C. Williams, and Craig E. Cameron. Unexpected sequences and structures of mtDNA required for efficient transcription from the first heavy-strand promoter. eLife 6: e27283 (2017). *contributed equally
  31. Divakaran Murugesapillai, Serge Bouaziz, L. James Maher III, Nathan E. Israeloff, Craig E. Cameron, and Mark C. Williams. Accurate nanoscale flexibility measurement of DNA and DNA-protein complexes by atomic force microscopy in liquid. Nanoscale 9: 11327-11337 (2017).
  32. M. Nabuan Naufer, David A. Murison, Ioulia Rouzina, Penny J. Beuning, and Mark C. Williams. Single-molecule mechanochemical characterization of E. coli pol III core catalytic activity. Protein Science 26: 1413-1426 (2017). Part of a special issue on Molecular Machines, edited by Carlos Bustamante.
  33. Divakaran Murugesapillai, Micah J. McCauley, L. James Maher III, and Mark C. Williams. Single-molecule studies of High Mobility Group B architectural DNA bending proteins. Biophysical Reviews 9: 17-40 (2017).
  34. Klara Post, Erik D. Olson, M. Nabuan Naufer, Robert J. Gorelick, Ioulia Rouzina, Mark C. Williams, Karin Musier-Forsysth, and Judith G. Levin. Mechanistic differences between HIV-1 and SIV nucleocapsid proteins and cross-species HIV-1 genomic RNA recognition. Retrovirology 13: 89 (2016).
  35. Ali A. Almaqwashi, Johanna Andersson, Per Lincoln, Ioulia Rouzina, Fredrik Westerlund, and Mark C. Williams. DNA intercalation optimized by two-step molecular lock mechanism. Scientific Reports 6: 37993 (2016).
  36. Ali A. Almaqwashi, Thayaparan Paramanathan, Ioulia Rouzina, and Mark C. Williams. Mechanisms of small molecule-DNA interactions probed by single-molecule force spectroscopy. Nucleic Acids Research 44: 3971-3988 (2016).
  37. Mark C. Williams. Review of Biophysics of DNA, by Alexander Vologodskii. Acta Crystallographica D 72: 599-600 (2016). Direct pdf download here.
  38. Ali A. Almaqwashi, Johanna Andersson, Per Lincoln, Ioulia. Rouzina, Fredrik Westerlund, and Mark C. Williams. Dissecting the dynamic pathways of stereoselective DNA threading intercalation. Biophysical Journal 110: 1255-1263 (2016).
  39. M. Nabuan Naufer, Kathryn E. Callahan, Pamela R. Cook, Cesar E. Perez-Gonzalez, Mark C. Williams, and Anthony V. Furano. L1 retrotransposition requires rapid ORF1p oligomerization, a novel coiled coil-dependent property conserved despite extensive remodeling. Nucleic Acids Research 44: 281-293 (2016).
  40. Micah J. McCauley, Ioulia Rouzina, Kelly A. Manthei, Robert J. Gorelick, Karin Musier-Forsyth, and Mark C. Williams. Targeted Binding of Nucleocapsid Protein Transforms the Folding Landscape of HIV-1 TAR RNA. Proceedings of the National Academy of Sciences USA 44: 13555-13560 (2015).
  41. Meriem Bahira, Micah J. McCauley, Ali Almaqwashi, Per Lincoln, Fredrik Westerlund, Ioulia Rouzina, and Mark C. Williams. A ruthenium dimer complex with a flexible linker slowly threads between DNA bases in two distinct steps. Nucleic Acids Research 43: 8856-8867 (2015).
  42. Hao Wu, Wei Wang, Nada Naiyer, Eric Fichtenbaum, Dominic F. Qualley, Micah J. McCauley, Robert J. Gorelick, Ioulia Rouzina, Karin Musier-Forsyth, and Mark C. Williams. Single aromatic residue location alters nucleic acid binding and chaperone function of FIV nucleocapsid protein. Virus Research 193: 39-51 (2014).
  43. Ali A. Almaqwashi, Thayaparan Paramanathan, Per Lincoln, Ioulia Rouzina, Fredrik Westerlund, and Mark C. Williams. Strong DNA deformation required for extremely slow DNA threading intercalation by a binuclear ruthenium complex. Nucleic Acids Research 42: 11634-11641 (2014).
  44. Divakaran Murugesapillai, Micah J. McCauley, Ran Huo, Molly H. Nelson Holte, Armen Stepanyants, L. James Maher III, Nathan E. Israeloff, and Mark C. Williams. DNA bridging and looping by HMO1 provides a mechanism for stabilizing nucleosome-free chromatin. Nucleic Acids Research 42: 8996-9004 (2014).
  45. Justin P. Peters, Lauren S. Mogil, Micah J. McCauley, Mark C. Williams, and L. James Maher, III. Mechanical properties of base-modified DNA are not strictly determined by base stacking or electrostatic interactions. Biophysical Journal 107: 448-459 (2014). See also New and Notable commentary by Jason Kahn.
  46. Wei Wang, Nada Naiyer, Mithun Mitra, Jialin Li, Mark C. Williams, Ioulia Rouzina, Robert J. Gorelick, Zhengrong Wu, and Karin Musier-Forsyth. Distinct nucleic acid interaction properties of HIV-1 nucleocapsid protein precursor NCp15 explain reduced viral infectivity. Nucleic Acids Research 42: 7145-7159 (2014).
  47. Kathy R. Chaurasiya, Micah J. McCauley, Wei Wang, Dominic F. Qualley, Tiyun Wu, Shingo Kitamura, Hylkje Geertsema, Denise S. B. Chan, Amber Hertz, Yasumasa Iwatani, Judith G. Levin, Karin Musier-Forsyth, Ioulia Rouzina and Mark C. Williams. Oligomerization transforms human APOBEC3G from an efficient enzyme to a slowly dissociating nucleic acid-binding protein. Nature Chemistry 6: 28-33 (2014). See also News and Views article by King and Wuite.
  48. Hao Wu, Mithun Mitra, M. Nabuan Naufer, Micah J. McCauley, Robert J. Gorelick, Ioulia Rouzina, Karin Musier-Forsyth and Mark C. Williams. Differential contribution of basic residues to HIV-1 nucleocapsid protein’s nucleic acid chaperone function and retroviral replication. Nucleic Acids Research 42: 2525-2537 (2014).
  49. Kathy R. Chaurasiya, Clarissa Ruslie, Michelle C. Silva, Lukas Voortman, Philip Nevin, Samer Lone, Penny J. Beuning, and Mark C. Williams. Polymerase manager protein UmuD directly regulates E. coli DNA polymerase III α binding to ssDNA. Nucleic Acids Research 41: 8959-8968 (2013).
  50. Micah J. McCauley, Emily M. Rueter, Ioulia Rouzina, L. James Maher III, and Mark C. Williams. Single molecule kinetics reveal microscopic mechanism by which HMGB proteins alter DNA flexibility. Nucleic Acids Research 41: 167-181 (2013).
  51. Hao Wu, Mithun Mitra, Micah J. McCauley, James A. Thomas, Ioulia Rouzina, Karin Musier-Forsyth, Mark C. Williams, and Robert J. Gorelick. Aromatic residue mutations reveal direct correlation between HIV-1 nucleocapsid protein’s nucleic acid chaperone activity and retroviral replication. Virus Research 171: 263-277 (2013).
  52. Thayaparan Paramanathan, Ioana Vladescu, Micah J. McCauley, Ioulia Rouzina, and Mark C. Williams. Force spectroscopy reveals the DNA structural dynamics that govern the slow binding of Actinomycin D. Nucleic Acids Research 40: 4925-4932 (2012).
  53. Jingyun Zhang, Micah J McCauley, L. James Maher III, Mark C Williams, and Nathan E Israeloff. Basic N-terminus of yeast Nhp6A regulates the mechanism of its DNA flexibility enhancement. Journal of Molecular Biology 416: 10–20 (2012).
  54. Kathy R. Chaurasiya, Hylkje Geertsema, Gaël Cristofari, Jean-Luc Darlix, and Mark C. Williams. A single zinc finger optimizes the DNA interactions of the nucleocapsid protein of the yeast retrotransposon Ty3. Nucleic Acids Research 40: 751–760 (2012).
  55. Micah J. McCauley and Mark C. Williams. Single-molecule biophysics: Untying a nanoscale knot. Nature Chemistry 3: 754–755 (2011).
  56. James D. Evans, Suresh Peddigari, Kathy R. Chaurasiya, Mark C. Williams, and Sandra L. Martin. Paired mutations abolish and restore the balanced annealing and melting activities of ORF1p that are required for LINE-1 retrotransposition Nucleic Acids Research 39: 5611-5621 (2011).
  57. Thayaparan Paramanathan, Micah J. McCauley, and Mark C. Williams. Studying Nucleic Acid – Drug Interactions at the Single Molecule Level Using Optical Tweezers. In “Methods for Studying DNA/Drug Interactions”, Meni Wanunu and Yitzhak Tor, eds. CRC Press (2011).
  58. Micah J. McCauley and Mark C. Williams. Measuring DNA-Protein Binding Affinity on a Single Molecule Using Optical Tweezers. In DNA Nanotechnology, Giampaolo Zuccheri and Bruno Samorì, eds. Humana Press, Springer, New York (2011).
  59. Mark C. Williams and Ioulia Rouzina. Force spectroscopy reveals DNA interactions with single-stranded DNA binding proteins and retroviral nucleic acid chaperones. In “Biophysics of DNA-protein interactions: From single molecules to biological systems”, Mark C. Williams and L. James Maher, III, eds. Springer, New York, pages 163-189 (2011).
  60. Book: “Biophysics of DNA-protein interactions: From single molecules to biological systems”, Mark C. Williams and L. James Maher, III, eds. Springer, New York (2011).
  61. Hao Wu, Ioulia Rouzina, and Mark C. Williams. “Single molecule stretching studies of RNA Chaperones”. RNA Biology 7: 712-723 (2010).
  62. Micah J. McCauley, Kathy R. Chaurasiya, Thayaparan Paramanathan, Ioulia Rouzina, and Mark C. Williams. “DNA stretching as a probe for nucleic acid interactions: Reply to Comments on ‘Biophysical characterization of DNA binding from single molecule
    force measurements'”. Physics of Life Reviews 7: 358-361 (2010).
  63. Kathy R. Chaurasiya, Thayaparan Paramanathan, Micah J. McCauley, and Mark C. Williams. Biophysical characterization of DNA binding from single molecule force measurements. Physics of Life Reviews 7: 299-341 (2010).
  64. Dominic F. Qualley, Kristen M. Stewart-Maynard, Fei Wang, Mithun Mitra, Robert J. Gorelick, Ioulia Rouzina, Mark C. Williams and Karin Musier-Forsyth. C-terminal domain modulates the nucleic acid chaperone activity of human T-cell leukemia virus type 1 (HTLV-1) nucleocapsid protein (NC) via an electrostatic mechanism. Journal of Biological Chemistry 285: 295-307 (2010).
  65. Mark C. Williams, Ioulia Rouzina, and Micah J. McCauley. Peeling back the mystery of DNA overstretching (Commentary). Proceedings of the National Academy of Sciences USA 106: 18047-18048 (2009). (direct to pdf)
  66. Leila Shokri, Ioulia Rouzina, and Mark C. Williams. Interaction of bacteriophage T4 and T7 single-stranded DNA binding proteins with DNA. Physical Biology 6: 025002 (2009).
  67. Jingyun Zhang, Micah J. McCauley, L. James Maher, III, Mark C. Williams, and N. E. Israeloff. Mechanism of DNA flexibility enhancement by HMGB proteins. Nucleic Acids Research 37: 1107-1114 (2009).
  68. Micah J. McCauley and Mark C. Williams. Optical Tweezers Experiments Resolve Distinct Modes of DNA-Protein Binding. Biopolymers 91: 265–282 (2009).
  69. Sandra L. Martin, Diane Bushman, Fei Wang, Patrick Wai-Lun Li, Ann Walker, Jessica Cummiskey, Dan Branciforte, and Mark C. Williams. A single amino acid substitution in ORF1 dramatically decreases L1 retrotransposition and provides insight into nucleic acid chaperone activity. Nucleic Acids Research 36: 5845-5854 (2008).
  70. Leila Shokri, Boriana Marintcheva, Mootaz Eldib, Andreas Hanke, Ioulia Rouzina, and Mark C. Williams. Kinetics and thermodynamics of salt-dependent T7 gene 2.5 protein binding to single- and double-stranded DNA. Nucleic Acids Research 36: 5668-5677 (2008).
  71. Kristen M. Stewart-Maynard, Margareta Cruceanu, Fei Wang, My-Nuong Vo, Robert J. Gorelick, Mark C. Williams, Ioulia Rouzina, and Karin Musier-Forsyth. Retroviral Nucleocapsid Proteins Display Non-equivalent Levels of Nucleic Acid Chaperone Activity. Journal of Virology 82: 10129-10142 (2008).
  72. Micah J. McCauley, Leila Shokri, Jana Sefcikova, Česlovas Venclovas, Penny J. Beuning, and Mark C.Williams. Distinct Double- and Single-Stranded DNA Binding of E. coli Replicative DNA Polymerase III Alpha Subunit. ACS Chemical Biology 3: 577-587 (2008). This work was also featured in a journal podcast.
  73. Kiran Pant, Leila Shokri, Richard L. Karpel, Scott W. Morrical, and Mark C. Williams. Modulation of T4 gene 32 protein DNA binding activity by the recombination mediator protein UvsY. Journal of Molecular Biology 380: 799-811 (2008).
  74. Leila Shokri, Micah J. McCauley, Ioulia Rouzina, and Mark C. Williams. DNA overstretching in the presence of glyoxal: Structural evidence of force–induced DNA melting. Biophysical Journal 95: 1248-1255 (2008).
  75. Thayaparan Paramanathan, Fredrik Westerlund, Micah J. McCauley, Ioulia Rouzina, Per Lincoln, and Mark C. Williams. Mechanically Manipulating the DNA Threading Intercalation Rate. Journal of the American Chemical Society (Communication) 130: 3752 -3753 (2008).
  76. Mark C. Williams, Ioulia Rouzina, and Richard L. Karpel. Quantifying DNA-protein interactions by single molecule stretching. Methods in Cell Biology 84: 517-540 (2008).
  77. Yasumasa Iwatani, Denise S.B. Chan, F. Wang, Kristen Stewart Maynard, Wataru Sugiura, Angela Gronenborn, Ioulia Rouzina, Mark C. Williams, Karin Musier-Forsyth, and Judith G. Levin. Deaminase-independent inhibition of HIV-1 reverse transcription by APOBEC3G. Nucleic Acids Research 35: 7096-7108 (2007).
  78. Micah J McCauley, Jeff Zimmerman, L. James Maher III, and Mark C Williams. HMGB Binding to DNA: Single and Double Box Motifs. Journal of Molecular Biology 374: 993-1004 (2007).
  79. Micah McCauley, Philip R. Hardwidge, L. J. Maher III, and Mark C. Williams. DNA binding proteins that alter nucleic acid flexibility, Proceedings of SPIE 6644: 664405 (2007).
  80. Mark C. Williams. Stuffing a virus with DNA: Dissecting viral genome packaging (Commentary). Proceedings of the National Academy of Sciences USA 104: 11125-11126 (2007).
  81. Ioana D. Vladescu, Micah J. McCauley, Megan E. Nuñez, Ioulia Rouzina, and Mark C. Williams. Quantifying force-dependent and zero-force DNA intercalation by single-molecule stretching. Nature Methods 4: 517-522 (2007). 
  82. Micah J. McCauley and Mark C. Williams, Mechanisms of DNA Binding Determined in Optical Tweezers Experiments. Biopolymers 85: 154-168 (2007).
  83. Leila Shokri, Boriana Marintcheva, Charles C. Richardson, Ioulia Rouzina, and Mark C. Williams. Single molecule force spectroscopy of salt-dependent bacteriophage T7 gene 2.5 protein binding to single-stranded DNA. Journal of Biological Chemistry 281: 38689-38696 (2006).
  84. Margareta Cruceanu, Andrew G. Stephen, Penny J. Beuning, Robert J. Gorelick, Robert J. Fisher, and Mark C. Williams. Single DNA molecule stretching measures the activity of chemicals that target the HIV-1 nucleocapsid protein Analytical Biochemistry 358: 159-170 (2006).
  85. Margareta Cruceanu, Robert J. Gorelick, Karin Musier-Forsyth, Ioulia Rouzina, and Mark C. Williams. Rapid kinetics of protein-nucleic acid interaction is a major component of HIV-1 nucleocapsid protein’s nucleic acid chaperone function. Journal of Molecular Biology 363: 867-877 (2006).
  86. Aleksandra Mihailović, Ioana Vladescu, Micah McCauley, Elaine Ly, Mark C. Williams, Eileen M. Spain, and Megan E. Nuñez. Exploring the Interaction of Ruthenium(II) Polypyridyl Complexes with DNA Using Single-Molecule Techniques. Langmuir 22: 4699-4709 (2006).
  87. Margareta Cruceanu, Maria A. Urbaneja, Catherine V. Hixson, Donald G. Johnson, Siddhartha A. Datta, Matthew J. Fivash, Andrew G. Stephen, Robert J. Fisher, Robert J. Gorelick, Jose R. Casas-Finet, Alan Rein, Ioulia Rouzina, and Mark C. Williams. Nucleic acid binding and chaperone properties of HIV-1 Gag and nucleocapsid proteins. Nucleic Acids Research 34: 593-605 (2006).
  88. Mark C. Williams, Ioulia Rouzina, and Richard L. Karpel. Thermodynamics and kinetics of DNA-protein interactions from single molecule force spectroscopy measurements. Current Organic Chemistry 10: 419-432 (2006).
  89. Igor M. Sokolov, Ralf Metzler, Kiran Pant, and Mark C. Williams. First passage time of N excluded-volume particles on a line. Physical Review E 72: 041102 (2005). 
  90. Ioana D. Vladescu, Micah J. McCauley, Ioulia Rouzina, and Mark C. Williams. Mapping the phase diagram of single DNA molecule force-induced melting in the presence of ethidium. Physical Review Letters 95: 158102 (2005).
  91. Ioulia Rouzina, Kiran Pant, Richard L. Karpel, and Mark C. Williams. Theory of electrostatically-regulated binding of T4 gene 32 protein to single- and double-stranded DNA. Biophysical Journal 89: 1941-1956 (2005).
  92. Igor M. Sokolov, Ralf Metzler, Kiran Pant, and Mark C. Williams. Target search of N sliding proteins on a DNA. Biophysical Journal 89: 895-902 (2005).
  93. Kiran Pant, Richard L. Karpel, Ioulia Rouzina, and Mark C. Williams. Salt dependent binding of T4 gene 32 protein to single- and double-stranded DNA: Single molecule force spectroscopy measurements. Journal of Molecular Biology 349: 317-330 (2005).
  94. Micah McCauley, Philip R. Hardwidge, L. James Maher III, and Mark C. Williams. Dual Binding Modes for an HMG Domain from Human HMGB2 on DNA. Biophysical Journal 89: 353-364 (2005).
  95. Sandra L. Martin, Margareta Cruceanu, Dan Branciforte, Patrick Wai-lun Li, Stanley C. Kwok, Robert S. Hodges, and Mark C. Williams. LINE-1 Retrotransposition Requires the Nucleic Acid Chaperone Activity of the ORF1 Protein. Journal of Molecular Biology 348: 549-561 (2005). 
  96. Kiran Pant, Richard L. Karpel, Ioulia Rouzina, and Mark C. Williams. Mechanical Measurement of Single Molecule Binding Rates: Kinetics of DNA Helix-Destabilization by T4 Gene 32 Protein. Journal of Molecular Biology 336: 851-870 (2004).
  97. Mark C. Williams, Kiran Pant, Ioulia Rouzina, and Richard L. Karpel. Single molecule force spectroscopy studies of DNA denaturation by T4 gene 32 protein. Spectroscopy – An International Journal 18: 203-211 (2004).
  98. Mark C. Williams. Thermodynamics of Pharmaceutical Systems: An Introduction for Students of Pharmacy. Drug Discovery Today 8: 395 (2003). 
  99. Kiran Pant, Richard L. Karpel, and Mark C. Williams. Kinetic Regulation of Single DNA Molecule Denaturation by T4 Gene 32 Protein Structural Domains. Journal of Molecular Biology 327: 571-578 (2003).
  100. A. Wynveen, K. Lidke, M. C. Williams, C. F. Giese, and J. W. Halley. Dynamics of Low Energy Helium Vapor Pulses Physical Review E 67: 026311 (2003).
  101. Mark C. Williams, Robert J. Gorelick, and Karin Musier-Forsyth. Specific zinc finger architecture required for HIV-1 nucleocapsid protein’s nucleic acid chaperone function Proceedings of the National Academy of Sciences USA 99: 8614-8619 (2002).
  102. Mark C. Williams. Optical Tweezers: Measuring Piconewton Forces, in Single Molecule Techniques, Petra Schwille, ed., a volume of the Biophysics Textbook Online, L. DeFelice, editor-in-chief, Biophysical Society, Bethesda, MD. Now available at https://www.biophysics.org/Portals/0/BPSAssets/Articles/williams.pdf (2002).
  103. Mark C. Williams and Ioulia Rouzina. Force Spectroscopy of Single DNA and RNA Molecules. Current Opinion in Structural Biology 12: 330-336 (2002).
  104. Mark C. Williams, Ioulia Rouzina, and Victor A. Bloomfield. Thermodynamics of DNA Interactions from Single Molecule Stretching Experiments. Accounts of Chemical Research 35: 159-166 (2002).
  105. Jay R. Wenner, Mark C. Williams, Ioulia Rouzina, and Victor A. Bloomfield. Salt dependence of the elasticity and overstretching transition of single DNA molecules Biophysical Journal 82: 3160-3169 (2002).
  106. Mark C. Williams, Ioulia Rouzina, Robert Gorelick, Karin Musier-Forsyth, and Victor A. Bloomfield. Mechanism for nucleic acid chaperone activity of HIV-1 nucleocapsid protein revealed by single molecule stretching. Proceedings of the National Academy of Sciences USA 98: 6121-6126 (2001).
  107. Mark C. Williams, Jay R. Wenner, Ioulia Rouzina, and Victor A. Bloomfield. Entropy and Heat Capacity of DNA Melting from Temperature Dependence of Single Molecule Stretching Biophysical Journal 80: 1932-1939 (2001).
  108. Mark C. Williams, Jay R. Wenner, Ioulia Rouzina, and Victor A. Bloomfield. The effect of pH on the overstretching transition of dsDNA: Evidence of force-induced DNA melting Biophysical Journal 80: 874-881 (2001).
  109. K. Lidke, M.C. Williams, A. Wynveen, and J.W. Halley. Gas Dynamics of Pulsed Low Energy Helium Beams. Journal of Low Temperature Physics 121: 351-356 (2000).
  110. Mark C. Williams, C.F. Giese, and J. W. Halley. Suspension of Superfluid Helium Using Cesium Coated Surfaces. Physical Review B 53: 6627-6633 (1996).
  111. C. F. Giese, K. Goetz, and M. C. Williams. Experimental Constraints on the Observation of the Condensate Fraction in Superfluid Helium Four by a new method. Physica B 194-196: 535-536 (1994).
  112. Mark C. Williams and R. T. Brundage. Stimulated emission cross sections and nonradiative relaxation of the 5L6′ state of trivalent americium in fluorozirconate glass. Physical Review B 45: 4561-4565 (1992).